A comparative biochemical analysis of glycosaminoglycans and proteoglycans in human orthotopic and heterotopic bone.

Glycosaminoglycans and proteoglycans are macromolecules of the bone and are involved in the assembly, maturation, mineralization, and maintenance of the extracellular matrix. Heterotopic ossification is the rapid development of calcified bone tissue at ectopic sites of the body, mainly in soft tissues that normally do not ossify. The aim of this study was to characterize the molecular profiles of glycosaminoglycans and proteoglycans in normal and heterotopic bone samples to assess whether differences exist between orthotopic and heterotopic bone.

Early failure of a zirconia femoral head prosthesis: fracture or fatigue?

Background: Zirconium ceramics are one of the most controversial prosthetic biomaterials with good mechanical properties on the one hand, but early failure incidents on the other hand. A case of an early failure of zirconia femoral head in a 73-year-old clergy man, who underwent a total hip arthroplasty 28 months before, is reported.

Method: The retrieved femoral head fragments, during revision surgery, were studied using scanning electron microscopy.