Synthesis, Structure and Biological Activity of 2-Methyl-5-nitro-6-phenylnicotinohydrazide-Based Hydrazones.

The synthetic availability and wide range of biological activity of hydrazides and hydrazones make them attractive subjects for investigation. In this study, we focused on synthesis of 2-methyl-5-nitro-6-phenylnicotinohydrazide-based hydrazones derived from the corresponding substituted aldehydes. The structure of the obtained compounds was studied using NMR spectroscopy and DFT calculations.

From a humorous post to a detailed quantum-chemical study: isocyanate synthesis revisited.

Isocyanates play an essential role in modern manufacturing processes, especially in polyurethane production. There are numerous synthesis strategies for isocyanates both under industrial and laboratory conditions, which do not prevent searching for alternative highly efficient synthetic protocols. Here, we report a detailed theoretical investigation of the mechanism of sulfur dioxide-catalyzed rearrangement of phenylnitrile oxide into phenyl isocyanate, which was first reported in 1977.

[Complex surgical treatment of recurrent post-injection abscess in a patient with systemic autoimmune disease].

The authors present complex surgical treatment of a patient with rheumatoid arthritis and persistent wound in the right gluteal region after previous surgical treatment of post-injection abscess. According to these data, active surgical treatment of wounds and purulent-necrotic lesions of any etiology and localization, augmented by modern agents for local and systemic therapy (including phage therapy) provide favorable functional and cosmetic results even in patients with systemic autoimmune diseases receiving glucocorticosteroids. It is important to assess the wound process considering not only clinical data, but also objective information of qualitative and quantitative microbiological and cytological examinations.

Morphology of Lymphoid Tissue in the Lungs of Guinea Pigs Infected with against the Background of Vaccine Immunity and the Action of Betulin and Its Derivatives.

Tuberculosis caused by is a serious problem for animal and human health worldwide. A promising concept for the design of anti-tuberculosis drugs is the conjugation of an immunogenic fraction isolated from bacterial vaccines with a stimulating component. Taking this principle as a basis, conjugates based on BCG antigens with betulin and its derivatives (betulonic and betulinic acids) were designed.

-Aminophosphonates 4-XCH-NH-CH(4-BrCH)-P(O)(OPr) (X = H, Br, MeO): Crystal structures, Hirshfeld surface analysis, computational studies and in silico molecular docking with the SARS-CoV-2 proteins.

We report structural and computational studies of three -aminophosphonates 4-XCH-NH-CH(4-BrCH)-P(O)(OPr), namely diisopropyl((4-bromophenyl)(phenylamino)methyl)phosphonate (X = H, ), diisopropyl((4-bromophenyl)((4-bromophenyl)amino)methyl)phosphonate (X = Br, ) and diisopropyl((4-bromophenyl)((4-methoxyphenyl)amino)methyl)phosphonate (X = MeO, ). The structures of - were fully confirmed by means of the P{H} and H NMR spectroscopy. Crystal structures of and are isostructural and each contain two independent molecules in the asymmetric unit cell.

A Family of Ethyl -Salicylideneglycinate Dyes Stabilized by Intramolecular Hydrogen Bonding: Photophysical Properties and Computational Study.

In this work we report solvatochromic and luminescent properties of ethyl -salicylideneglycinate (), ethyl -(5-methoxysalicylidene)glycinate (), ethyl -(5-bromosalicylidene)glycinate (), and ethyl -(5-nitrosalicylidene)glycinate () dyes. - correspond to a class of -salicylidene aniline derivatives, whose photophysical properties are dictated by the intramolecular proton transfer between the OH-function and the imine N-atom, affording tautomerization between the enol-imine and keto-enamine forms. Photophysical properties of - were studied in different pure non-polar and (a)protic polar solvents as well as upon gradual addition of NEt, NaOH, and CHSOH.

[Implementation of modern trends in the methods of the ventilation support in the new apparatus for artificial lung ventilation Avenir-221 P].

In the new ventilator Avenir-221 P modern lines of development of ventilation support in intensive therapy of adults and children are implemented. The capacities of the ventilator are successfully combined with its technical decisions which include microprocessor parametrical controlling, programming-controlled electric drive, an information saturation, intuitively clear control system, protection against interruption of power supply sources and oxygen feeding falls. A set of functional characteristics (modes VCV, PCV, Ass/Contr, PSV, SIMV, PEEP, Sigh, etc.

[Analysis and realization of new methods of testing the artificial ventilation of lungs (AVL) equipment].

The requirements applicable to the canal of the artificial ventilation of the lungs (AVL), volume measuring and to methods of appropriate monitoring based on GOST R ISO 10651.1-99 "Medical equipment of artificial ventilation of the lungs. Part 1.