Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores.

Risk prediction in patients with heart failure (HF) is essential to improve the tailoring of preventive, diagnostic, and therapeutic strategies for the individual patient, and effectively use health care resources. Risk scores derived from controlled clinical studies can be used to calculate the risk of mortality and HF hospitalizations. However, these scores are poorly implemented into routine care, predominantly because their calculation requires considerable efforts in practice and necessary data often are not available in an interoperable format.

An Apple Watch Dashboard for HiGHmed Heart Insufficency Patients.

Wearables are commercially available devices allowing continuous monitoring of users' health parameters. Their easy availability, increasing accuracy and functionality render them relevant for medical practice, specifically for longitudinal monitoring. There are clear benefits for the health care system, such as the opportunity of timely interventions by monitoring a patient during his daily life, resulting in a cost reduction in medical care and improved patient well-being.

Preliminary Analysis of Structured Reporting in the HiGHmed Use Case Cardiology: Challenges and Measures.

The HiGHmed consortium aims to create a shared information governance framework to integrate clinical routine data. One challenge is the replacement of unstructured reporting (e.g.

MedEx - Data Analytics for Medical Domain Experts in Real-Time.

Translational research in the medical sector is dependent on clear communication between all participants. Visualization helps to represent data from different sources in a comprehensible way across disciplines. Existing tools for clinical data management are usually monolithic and technically challenging to set up, others require a transformation into specific data models while providing mostly non-interactive visualizations or being specialized to very particular use cases.

The role of 11-cis-retinyl esters in vertebrate cone vision.

A cycle of cis-to-trans isomerization of the chromophore is intrinsic to vertebrate vision where rod and cone photoreceptors mediate dim- and bright-light vision, respectively. Daylight illumination can greatly exceed the rate at which the photoproduct can be recycled back to the chromophore by the canonical visual cycle. Thus, an additional supply pathway(s) must exist to sustain cone-dependent vision.