Publications by authors named "Aljosa Stankovic"
Article Synopsis
- Researchers explored nanobrachytherapy, an alternative to traditional brachytherapy, using intratumoral injections of radionuclide-labeled superparamagnetic iron oxide nanoparticles (SPIONs) to treat solid tumors more effectively than intravenous methods.
- The nanoparticles were coated with meso-1,2-dimercaptosuccinic acid (DMSA) and radiolabeled with Lutetium-177 (Lu), showing stable bonding and minimal leakage post-injection in mouse tumor models.
- Testing demonstrated that a low dose of Lu-DMSA@SPIONs led to high therapeutic efficacy localized around the injection site, indicating they can be safe and effective for targeted tumor treatment without requiring higher or repeated doses.
Combined radionuclide therapy with magnetic nanoparticles-mediated hyperthermia has been under research focus as a promising tumor therapy approach. The objective of this study was to investigate the potential of I-radiolabeled superparamagnetic iron oxide nanoparticles (SPIONs) prepared as the ~40 nm flower-shaped structures with excellent heating efficiency (specific absorption rate at H = 15.9 kA∙m and resonant frequency of 252 kHz was 123.
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