Outcome with topical sirolimus for port wine stain malformations after unsatisfactory results with pulse dye laser treatment alone.

Unlabelled: We used a topical formulation of sirolimus for treating port wine stain (PWS). Although pulsed dye laser (PDL) is the current treatment of choice for PWS, fast neovascularization after treatment is a major drawback. With PDL therapy there has been insufficient improvement and frustrating side effects.