Publications by authors named "Alja Crnej"
Postoperative endoscopic cyclophotocoagulation (CPC) for the treatment of glaucoma in patients with Boston keratoprosthesis type II (BKPro II) was first described in 2017 by Poon et al. (). As we do not have this device, we present a case of transscleral CPC (TSCPC), in a BKPro II patient who had graft versus host disease and developed uncontrolled glaucoma.
View Article and Find Full Text PDFPurpose: To review clinical aspects and cellular and molecular steps in the development of long-term glaucoma after corneal surgery or acute trauma-especially the pivotal role of tumor necrosis factor alpha (TNF-α), the rapidity of the secondary damage to the retinal ganglion cells, and the clinical promise of early antiinflammatory intervention.
Methods: A series of laboratory studies on post-injury and post-surgery glaucoma have been compared to clinical outcome studies on the subject, focusing particularly on the vulnerability of the retinal ganglion cells. Alkali burn to the cornea of mice and rabbits served as the main experimental model.
Purpose:: To evaluate the capsular bag performance and posterior capsule opacification development of two intraocular lenses differing in material and design.
Methods:: This study included patients who were scheduled for cataract surgery and compared a hydrophilic intraocular lens (Super flex intraocular lens; Rayner Surgical, Worthing, UK) with a hydrophobic intraocular lens (AcrySof SA60AT; Alcon, Fort Worth, TX, USA). Follow-ups were performed 1 month and 2 years after cataract surgery, including a slit lamp examination and retroillumination images.
Purpose: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases.
Methods: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed.
Results: Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases.
Methods for assessing forward and backward light scatter in patients with cataract.
J Cataract Refract Surg
August 2017
Purpose: To compare objective methods for assessing backward and forward light scatter and psychophysical tests in patients with cataracts.
Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Design: Prospective case series.
Purpose: To quantitatively evaluate the angle anatomy in eyes with the Boston type I keratoprosthesis (B-KPro) differing in the back plate (BP) material and size using anterior segment optical coherence tomography.
Methods: B-KPro eyes with poly(methyl methacrylate) (PMMA) (7.0 and 8.
Purpose: To quantify the severity of ocular pain in patients with dry eye disease (DED) and evaluate factors associated with pain severity.
Design: Cross-sectional study.
Methods: Eighty-four patients with DED were asked to score their severity level of ocular pain using a 10-point scale, with 10 indicating the most severe pain.
Purpose: Patients' perceptions of the effectiveness of a treatment, or perceived treatment effectiveness (PTE), play an important role in medicine. This study aimed to evaluate patients' PTE in dry eye disease (DED) and investigate factors contributing to these patients' perceptions.
Methods: This cross-sectional study included 66 patients with DED.
Purpose: Although it has been known that patients' perspectives on their disease can significantly affect their level of functional disability as well as disease outcome, limited data are available on patients' perceptions of their dry eye disease (DED). The aim of this questionnaire-based study was to evaluate patients' perspectives on their DED.
Methods: This cross-sectional study included 91 patients with DED.
Purpose: To compare the effects of post-penetrating keratoplasty (PK) and post-keratoprosthesis (KPro) surgery-related inflammation on the posterior segment of the eye and to assess inhibition of tumor necrosis factor alpha (TNFα) and interleukin-1 beta (IL-1β) on these effects.
Methods: BALB/C (syngeneic) or C57BL/6 (allogeneic) corneas were transplanted onto BALB/C host beds as part of PK or miniature KPro (m-KPro) implantation. Intraocular pressure (IOP) was measured via an intracameral pressure sensor; tissues were harvested and analyzed 8 weeks after surgery.
Purpose: To report our experience using intravenous infliximab for the treatment of tissue melt after Boston keratoprosthesis (B-KPro) types I and II in patients with autoimmune disease.
Methods: Case series.
Results: We identified four patients who were treated with intravenous infliximab in the context of tissue melt after B-KPro.
Purpose: Idiopathic vitritis is a poorly understood complication after Boston keratoprosthesis surgery with unclear etiology. We sought to determine whether an association exists between periprosthetic corneal tissue loss and the development of idiopathic vitritis in keratoprosthesis recipients.
Methods: Thirteen Boston type I keratoprosthesis recipient eyes with a history of idiopathic vitritis and 34 type I keratoprosthesis recipient eyes with no history of idiopathic vitritis underwent anterior segment optical coherence tomography (AS-OCT) at a median time postoperatively of 2.
Purpose: The aim of this study was to revisit the clinical paradigm attributed to Boston keratoprosthesis recipients presenting with idiopathic vitreous inflammation.
Methods: A retrospective chart review was performed of keratoprosthesis recipients at Massachusetts Eye and Ear Infirmary, from January 2000 to August 2013, for demographic data, indication(s) for surgery, timing and presentation of vitreous inflammation, and best-corrected visual acuity at baseline, on presentation, and after resolution of vitritis.
Results: Twenty-three (23 eyes) of 346 patients developed idiopathic vitreous inflammation after keratoprosthesis implantation.
Corneal inflammation after miniature keratoprosthesis implantation.
Invest Ophthalmol Vis Sci
December 2014
Purpose: To compare corneal inflammation after syngeneic and allogeneic penetrating keratoplasty (PK) with miniature Keratoprosthesis (m-KPro) implantation in mice.
Methods: BALB/C (syngeneic) or C57BL/6 (allogeneic) corneas were transplanted onto BALB/C host beds as part of PK or m-KPro implantation. Corneal inflammation was assessed by determining the frequencies of CD45(+) leukocytes, CD4(+) T cells, CD11b(+) cells, and Gr-1(+) granulocytes/monocytes by flow cytometry at 2, 4, and 8 weeks post transplantation.
Capsular bag performance of a hydrophobic acrylic 1-piece intraocular lens.
J Cataract Refract Surg
January 2015
Purpose: To compare parameters after 1-piece and 3-piece intraocular lens (IOL) implantation.
Setting: Moorfields West End Clinic, London, United Kingdom, and Hanusch Hospital, Vienna, Austria.
Design: Prospective randomized controlled trial.
Purpose: To establish a murine model for keratoprosthesis.
Methods: A miniature keratoprosthesis (m-KPro) device was created consisting of a poly[methyl methacrylate] front part and a titanium back plate, designed after the Boston KPro, which is in widespread clinical use. BALB/c mice were used and a 2 mm in diameter donor cornea was punched out.
Purpose: To compare forward and backward light scattering measurements to quantify posterior capsule opacification (PCO).
Setting: Vienna Institute for Research in Ocular Surgery, Vienna, Austria.
Design: Prospective single-center study.
Purpose: The aim of this study was to evaluate glaucoma onset and progression after implantation of Boston Keratoprostheses (B-KPro) and the role of glaucoma surgery.
Methods: Records of patients with B-KPro implantation during 2004 to 2009 were reviewed. Parameters relevant to B-KPro surgery and glaucoma status were recorded.
Purpose: To compare the ocular wave-front of eyes with silicone Intraocular lens (IOLs) with aspheric and spherical optics after cataract surgery, taking into account the patient's pupil size under reading conditions and after pupil dilatation.
Methods: In this institutional prospective, randomized, controlled, patient and examiner masked, bilateral trial with intra-individual comparison, 60 eyes of 30 patients with bilateral age-related cataract were included. Each patient received a spherical IOL (CeeOn Edge, 911A, AMO, Santa Ana, CA, USA) in one eye and an aspheric IOL (Tecnis, Z9000, AMO) in the contra-lateral eye.
Purpose: To compare the astigmatism-reducing effect of a toric intraocular lens (IOL) and peripheral corneal relaxing incisions (PCRIs).
Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Design: Prospective masked bilateral randomized study.
Purpose: To compare capsular bag stability and posterior capsule opacification (PCO) of a plate-haptic intraocular lens (IOL) and a standard three-piece open-loop-haptic IOL of the same acrylic material.
Methods: In this randomised bilateral patient-masked and examiner-masked study, each patient received a microincision cataract surgery IOL (MICS IOL; Acri.Smart 46S=CT SHERIS 209M) in one eye and a small incision cataract surgery IOL (SICS IOL; AcriLyc 53N = CT 53N, both Carl Zeiss Meditec AG, Germany) as a control in the contralateral eye.
Purpose: To assess whether fluorescein dye in the tear film results in a clinically relevant change in central corneal thickness (CCT), as measured with Scheimpflug imaging (Pentacam HR; Oculus, Wetzlar, Germany). The study was conducted at Moorfields Eye Hospital NHS Foundation Trust.
Methods: In this prospective, randomized, controlled, single-center study on healthy volunteers, CCT was measured using rotating Scheimpflug imaging and partial coherence interferometry technique.
Posterior capsule opacification and capsular bag performance of a microincision intraocular lens.
J Cataract Refract Surg
November 2011
Purpose: To assess the axial stability and posterior capsule opacification (PCO)-inhibiting efficacy of a microincision hydrophilic intraocular lens (IOL) (Idea 613 XC) and a standard hydrophobic open-loop acrylic IOL (Acrysof SA60AT).
Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Design: Clinical trial.
Impact of intraocular lens haptic design and orientation on decentration and tilt.
J Cataract Refract Surg
October 2011
Purpose: To assess the effect of intraocular lens (IOL) orientation (vertical versus horizontal) and haptic design (1-piece versus 3-piece) on centration and tilt using a Purkinje meter.
Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Design: Randomized pilot study with intrapatient comparison.
Rotational stability of a single-piece toric acrylic intraocular lens.
J Cataract Refract Surg
October 2010
Purpose: To assess the rotational stability of a single-piece toric hydrophobic acrylic intraocular lens (IOL) during the first 6 postoperative months.
Setting: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Design: Prospective case series.