Publications by authors named "Aliza Siebenaller"
Article Synopsis
- Rodents can heal their bladders naturally after surgery, and specific proteins like YAP/WWTR1 and BDNF help this healing process.
- Researchers studied how these proteins affect bladder muscle cells during injury recovery, using rats as models to observe cell movement.
- The study found that when bladder cells were injured, certain signals increased cell movement and healing, but blocking these signals slowed down the recovery.
The abdominal wall (external oblique (EO), internal oblique (IO), rectus abdominis (RA), and transverse abdominis (TrA)) is a functionally and anatomically integrated group of muscles. While the passive mechanical properties of the individual abdominal muscles have been studied previously, their contractile properties have yet to be described. Muscle samples were taken from the EO, IO, RA, and TrA of 6 Sprague-Dawley rats.
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- The study looked at how to help bladders work better after they get blocked, especially when this is due to conditions like prostate problems.
- The researchers used a medicine called rapamycin to see if it could help fix bladder issues after the blockage was removed in rats.
- They found that rapamycin improved the bladders' ability to empty and worked better than a placebo, which helps scientists understand how to treat these types of bladder problems.
Chronic bladder obstruction and bladder smooth muscle cell (SMC) stretch provide fibrotic and mechanical environments that can lead to epigenetic change. Therefore, we examined the role of DNA methylation in bladder pathology and transcriptional control. Sprague-Dawley female rats underwent partial bladder obstruction by ligation of a silk suture around the proximal urethra next to a 0.
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