Publications by authors named "Aliza Naz"
Recursive dynamics of GspE through machine learning enabled identification of inhibitors.
Comput Biol Chem
December 2024
Article Synopsis
- The Type II secretion system (T2SS) in pathogenic bacteria like Achromobacter xylosoxidans is critical for virulence, with the ATPase GspE playing a vital role in powering this system.
- A machine learning approach was used to screen drug libraries, identifying potential inhibitors targeting GspE through molecular docking and extensive dynamics simulations.
- The study highlighted Asinex-BAS00263070-28551 as a promising drug candidate, which interacts effectively with GspE, but further experimental validation is necessary to confirm its therapeutic potential.
Over the past few years, COVID-19 has caused widespread suffering worldwide. There is great research potential in this domain and it is also necessary. The main objective of this study was to identify potential inhibitors against acid sphingomyelinase (ASM) in order to prevent coronavirus infection.
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