Endoscopic Type 1 Tympanoplasty: Evaluation of Clinical Success and Hearing Improvement.

Objective: This study aimed to assess the functional and clinical outcomes of endoscopic Type 1 tympanoplasty in patients with chronic otitis media and tympanic membrane perforations, focusing on hearing improvement and graft success rates.

Methods: This retrospective study included 46 patients with dry tympanic membrane perforations who underwent endoscopic Type 1 tympanoplasty. Audiometric data, including pure tone averages (PTA) and air-bone gap (ABG) measurements at four frequencies (500, 1000, 2000, and 4000 Hz), were collected preoperatively and postoperatively.

Letter to the Editor: A New Guiding Suturing Technique for Reshaping of the Antihelix in Patients with Prominent Ears.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.

Dysregulation of alternative splicing is a transcriptomic feature of patient-derived fibroblasts from CAG repeat expansion spinocerebellar ataxias.

The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of rare dominantly inherited neurodegenerative diseases characterized by progressive ataxia. The most common mutation seen across the SCAs is a CAG repeat expansion, causative for SCA1, 2, 3, 6, 7, 12 and 17. We recently identified dysregulation of alternative splicing as a novel, presymptomatic transcriptomic hallmark in mouse models of SCAs 1, 3 and 7.

CAG repeat-selective compounds reduce abundance of expanded CAG RNAs in patient cell and murine models of SCAs.

Spinocerebellar ataxias (SCAs) are a genetically heterogenous group of devastating neurodegenerative conditions for which clinical care currently focuses on managing symptoms. Across these diseases there is an unmet need for therapies that address underlying disease mechanisms. We utilised the shared CAG repeat expansion mutation causative for a large subgroup of SCAs, to develop a novel disease-gene independent and mechanism agnostic small molecule screening approach to identify compounds with therapeutic potential across multiple SCAs.

Health conditions of first-degree relatives of children with familial Mediterranean fever.

Background: Given the strong genetic background of familial Mediterranean fever (FMF), the frequently reported co-existing diseases in children with FMF should also be investigated in other family members. Therefore, we aimed to examine the medical conditions of first-degree relatives (FDRs) of our pediatric patients with FMF in the present study.

Methods: Chronic diseases of FDRs of pediatric 449 FMF, 147 juvenile idiopathic arthritis (JIA) patients and 93 healthy controls (HC) were questioned during their routine clinical visits for 9 consecutive months.

Reinforcement in Laparoscopic Sleeve Gastrectomy: Is It Effective?

Background: Despite the success of bariatric surgery in treating obesity, it can still lead to complications. The most serious and feared technical complications are bleeding and leakage from the gastric staple line. In this study, stapler line reinforcement was investigated to determine whether it affects postoperative leakage and bleeding rates and their management.

Vitamin D Deficiency as a Risk Factor of Tinnitus: An Epidemiological Study.

Objectives: Vitamin D deficiency as a risk factor of tinnitus has not been well known. We tried to evaluate the association between the serum 25-(OH) vitamin D levels and tinnitus among the Korean population to propose the possible role of serum vitamin D in patients with tinnitus.

Methods: This cross-sectional study investigated the potential risk factors of tinnitus in relation to serum 25(OH)D levels within the Korean population.

The variations of osseous structure of the ınternal acoustic canal: an anatomical study.

Objectives: The internal acoustic meatus is an osseous canal that connects the inner ear to the posterior cranial fossa. It is located in the petrous portion of the temporal bone. A thin cribriform osseous plate known as the fundus is situated at the lateral end of the canal.

Enhancing Postoperative Cochlear Implant Care With ChatGPT-4: A Study on Artificial Intelligence (AI)-Assisted Patient Education and Support.

Background: Cochlear implantation is a critical surgical intervention for patients with severe hearing loss. Postoperative care is essential for successful rehabilitation, yet access to timely medical advice can be challenging, especially in remote or resource-limited settings. Integrating advanced artificial intelligence (AI) tools like Chat Generative Pre-trained Transformer (ChatGPT)-4 in post-surgical care could bridge the patient education and support gap.

Thermal processing of pomegranate seed oils underscores their antioxidant stability and nutritional value: Comparison of pomegranate seed oil with sesame seed oil.

In the present study, the oxidative stability and antioxidant activity of seed oils were investigated in three Iranian pomegranate cultivars, Shirin Khafr, Torsh Sabz, and Rabab, along with the sesame ( L. cv Dezful) seed oil. Punicic acid was the primary fatty acid in the pomegranate seed oils, with contents ranging from 75.

Hearing Rehabilitation With a Chat-Based Mobile Auditory Training Program in Experienced Hearing Aid Users: Prospective Randomized Controlled Study.

Background: Hearing rehabilitation with auditory training (AT) is necessary to improve speech perception ability in patients with hearing loss. However, face-to-face AT has not been widely implemented due to its high cost and personnel requirements. Therefore, there is a need for the development of a patient-friendly, mobile-based AT program.

Transhumanism: Integrating Cochlear Implants With Artificial Intelligence and the Brain-Machine Interface.

The integration of cochlear implants (CI) with brain-machine interfaces (BMIs) and artificial intelligence (AI) within the framework of transhumanism is revolutionary and this editorial highlights how this synergy can transcend human sensory experiences and auditory rehabilitation. The potential of this amalgamation extends beyond restoring auditory function to enhancing human capabilities, marking a transformative step towards a future where technology harmoniously extends human faculties.

Efficacy of intratympanic steroid therapy for severe and profound sudden sensorineural hearing loss.

Background: Intratympanic steroids (ITS) in treating sudden sensorineural hearing loss (SSNHL) have become more widespread.

Aim: This study investigates whether ITS treatment provides additional benefits when combined with systemic steroids (SS) in patients with severe and profound SSNHL.

Materials And Methods: Patients diagnosed with severe and profound SSNHL were divided into two groups: SS group and SS combined with ITS group.

Be or Not to Be With ChatGPT?

In the ever-evolving realm of scientific research, this letter underscores the vital role of ChatGPT as an invaluable ally in manuscript creation, focusing on its remarkable grammar and spelling error correction capabilities. Furthermore, it highlights ChatGPT's efficacy in expediting the manuscript preparation process by streamlining the collection and highlighting critical scientific information. By elucidating the aim of this letter and the multifaceted benefits of ChatGPT, we aspire to illuminate the path toward a future where scientific writing achieves unparalleled efficiency and precision.

"Bot or Not": Turing Problem in Otolaryngology.

The aim of this article is to shed light on the evolving landscape of artificial intelligence (AI) integration in otolaryngology and its implications, particularly focusing on the ethical considerations surrounding AI applications, and to highlight the potential benefits of ChatGPT in patient management and scientific research within otolaryngology while emphasizing the necessity for ethical guidelines and validation processes. Ultimately, the article seeks to encourage a responsible and informed approach to AI adoption in otolaryngology, promoting collaboration between AI and healthcare professionals for the betterment of science and human well-being.

Angles of Needle Insertion for True Vocal Fold Access Via the Thyrohyoid and Cricothyroid Membranes of the Larynx.

Objective: This study aims to provide an analysis of the cricothyroid and thyrohyoid membrane approaches for laryngeal injections in cadaveric vocal cords. The primary objective is to determine the optimal techniques, needle trajectories, and anatomical landmarks for accessing different regions of the vocal cords percutaneously.

Materials And Methods: The study was conducted on 23 adult cadavers, consisting of 8 females and 15 males.

Endoscope-assisted rhinoplasty: enhancing precision or extending procedure duration?

Objective: The endoscope in rhinology surgeries is a modern tool that can provide significant benefits. By offering a better view of intranasal pathologies, it can assist in diagnosing and treating them more conveniently. In particular, in cases where minimal nasal invasion is required, endoscope assistance can be especially beneficial during short and comfortable periods of rhinoplasty surgery.

Assessing Auditory and Cochlear Function in Alopecia Areata Patients: Exploring the Link to Cochlear Melanocyte Damage.

Introduction Alopecia areata (AA) is an autoimmune disorder causing hair loss, including eyebrows, eyelashes, and body hair, primarily due to melanocyte impact. Though the precise AA melanocyte hearing loss mechanisms are not fully clear, it's speculated that cochlear melanocyte inflammation could disrupt endolymph production, which is necessary for sound signal transmission. Cochlear melanocytes maintain crucial potassium ion levels, which are pivotal for hearing.

Widespread alternative splicing dysregulation occurs presymptomatically in CAG expansion spinocerebellar ataxias.

The spinocerebellar ataxias (SCAs) are a group of dominantly inherited neurodegenerative diseases, several of which are caused by CAG expansion mutations (SCAs 1, 2, 3, 6, 7 and 12) and more broadly belong to the large family of over 40 microsatellite expansion diseases. While dysregulation of alternative splicing is a well defined driver of disease pathogenesis across several microsatellite diseases, the contribution of alternative splicing in CAG expansion SCAs is poorly understood. Furthermore, despite extensive studies on differential gene expression, there remains a gap in our understanding of presymptomatic transcriptomic drivers of disease.