A perspective on a precision approach to pain in cancer; moving beyond opioid therapy.

Purpose: Cancer-related pain is primarily treated with opioids which while effective can add significant patient burden due to side effects, associated stigma, and timely access. The purpose of this perspective discussion is to argue for a precision approach to pain in cancer based on a biopsychosocial and spiritual model which we argue can offer a higher quality of life while limiting opioid use.

Conclusions: Pain in cancer represents a heterogenous process with multiple contributing and modulating factors.