Exploring band-free Raman microspectrometry combined with PCA and MCR-ALS for size-resolved forensic analysis of uranium in aerosols in a model nuclear atmosphere.

Achieving non-destructive micrometer-scale molecular and structural analysis of uranic materials in atmospheric aerosols with traditional methodologies is a challenge. Spatially resolved analysis of uranium in actinide-bearing aerosols is critical for nuclear forensics. Although laser Raman microspectrometry enables this, for the normally low uranium concentrations in the aerosols the spectra are indiscernible (band-free) against pronounced background: trace analysis requires a push in analytical strategy.

Rapid diagnosis of malaria by chemometric peak-free LIBS of trace biometals in blood.

Laser Induced Breakdown Spectroscopy (LIBS) trace atomic species of diseased biofluids are subtle (peak-free) in complex spectra. Trace analysis requires a considerable push in analytical strategy. Enabling LIBS with chemometrics can help identify, extract, analyze and interpret the trace species' spectral signatures to give an insight on the biophysiological status of the bodies from which the biofluids originate.