Publications by authors named "Aliva Naik"
The compound 2,3-dehydrosilychristin, a flavonolignan linked to silychristin and silymarin, remains intriguing due to its challenging isolation from silymarin. While silymarin has been the exclusive source of flavonolignans - silybin, silychristin and silydianin - 2,3-dehydrosilychristin is reported in this study from Linn. leaves.
View Article and Find Full Text PDFFlavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer.
J Enzyme Inhib Med Chem
December 2023
Article Synopsis
- - The study explored modifying the flavone structure by using organopalladium-catalyzed C-C bond formation, focusing on changes at position 7 and the effects of various substituents on its antitumor activity.
- - A compound featuring a furyl arm and a 4-fluoro phenyl ring demonstrated strong antitumor effects against Ishikawa cell lines through dual inhibition of PARP and tubulin.
- - The findings indicated that this compound could induce apoptosis, autophagy, and cause cell cycle arrest at the G2/M phase, leading to its designation as an effective dual inhibitor for treating endometrial cancer.