Publications by authors named "Alistair D R Grey"
Article Synopsis
- - The study aimed to test the feasibility of a randomized controlled trial (RCT) examining the effects of aspirin and vitamin D3 in patients with low-risk prostate cancer who are undergoing active surveillance and have undergone Prolaris® testing.
- - Out of 130 eligible patients, 104 (80%) participated, with 94 completing treatment; Prolaris® testing succeeded in 81% of diagnostic biopsies.
- - The findings revealed a 12-month disease progression rate of 43.3% among participants, with high treatment adherence (91%) in non-progressing patients, though there were two serious adverse events linked to aspirin.
Article Synopsis
- The study investigates the effectiveness of multiparametric ultrasound compared to multiparametric MRI in diagnosing clinically significant prostate cancer among at-risk patients.
- Conducted in seven UK hospitals, the research involved patients undergoing both imaging techniques, followed by targeted biopsies regardless of test results.
- The goal was to assess the agreement in identifying suspicious lesions between the two methods, specifically looking at their capability to detect significant cancer indicated by higher Gleason scores.
Article Synopsis
- The text discusses the evolving role of transrectal ultrasound (TRUS) in diagnosing prostate cancer, particularly in pre-biopsy localization and targeting compared to multiparametric MRI (mpMRI).
- It differentiates between the use of TRUS for basic zonal biopsies and its advanced role in identifying and targeting abnormal lesions.
- The text also covers the use of AI in lesion detection, comparing the cost, availability, contraindications, and diagnostic accuracy of TRUS versus mpMRI.
Article Synopsis
- The study aimed to assess how effective multiparametric magnetic resonance imaging (mpMRI) is in identifying significant prostate cancer compared to transperineal sector biopsy (TPSB) as a reference standard.
- Researchers analyzed data from 201 patients who underwent TPSB after receiving mpMRI scans, where a uro-radiologist assigned scores indicating the likelihood of significant cancer based on the prostate imaging reporting and data system (PI-RADS).
- Results showed that mpMRI, particularly with low PI-RADS scores (1 or 2), had a high sensitivity (97%) for detecting significant cancer, which suggests it could be an important tool in clinical decision-making regarding prostate cancer biopsies.
Tamsulosin MR and OCAS (modified release and oral controlled absorption system): current therapeutic uses.
Expert Opin Pharmacother
April 2008
Article Synopsis
- Tamsulosin is primarily used for treating urinary issues related to benign prostatic hyperplasia but is also effective for various genitourinary conditions in both genders.
- The review examined the use of tamsulosin through research published between 1975 and 2007, focusing on its therapeutic applications linked to alpha(1) receptors.
- Tamsulosin is recognized as a powerful third-generation selective alpha(1A) adrenoceptor-blocker, which has become a preferred alternative to more invasive treatments like surgical procedures for managing benign prostatic hyperplasia.