Publications by authors named "Alison-Michelle Naujack"
Article Synopsis
- Metabolic dysfunction-associated steatohepatitis (MASH) is linked to inflammation and fatty liver, and its progression may be influenced by reduced thyroid hormone signaling, specifically through decreased DIO1 and THRB expression.
- Research revealed that miR-34a-5p is increased in MASH patients and may play a role in suppressing thyroid hormone activity in the liver by targeting genes like THRB and DIO1.
- Additionally, DNA methylation changes in the THRB gene were found in MASH patients, potentially contributing to a state of resistance to thyroid hormones as the disease progresses.
De novo lipogenesis (DNL) in visceral adipose tissue (VAT) is associated with systemic insulin sensitivity. DNL in VAT is regulated through ChREBP activity and glucose uptake through Glut4 (encoded by ). expression, ChREBP activity, and DNL are decreased in obesity, the underlying cause however remains unidentified.
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