Publications by authors named "Alison Pullan"
Article Synopsis
- - The REDES study analyzed patients with severe eosinophilic asthma to see how many achieved clinical remission after 1 year of treatment with mepolizumab, focusing on a comprehensive definition of remission including factors like being free from oral corticosteroids and asthma exacerbations.
- - Results showed that 37% of patients met a three-component definition of remission, and 30% met a four-component definition, a significant increase from only 2% and 3% at the start of the study.
- - The study suggests that multi-component clinical remission is an achievable goal for some patients on mepolizumab, but more research is needed to better understand predictors of successful treatment outcomes and to aid in managing the disease.
Background: Preliminary studies using the FENIX™ (Torax Medical, Minneapolis, MN, USA) magnetic sphincter augmentation device suggest that it is safe to use for the treatment of adult faecal incontinence, but efficacy data are limited.
Objective: To compare FENIX with sacral nerve stimulation for the treatment of adult faecal incontinence in terms of safety, efficacy, quality of life and cost-effectiveness.
Design, Setting And Participants: Multicentre, parallel-group, unblinded, randomised trial comparing FENIX with sacral nerve stimulation in participants suffering moderate to severe faecal incontinence.
Background: Although surgical resection has been considered the only curative option for colorectal liver metastases, thermal ablation has recently been suggested as an alternative curative treatment. There have been no adequately powered trials comparing surgery with thermal ablation.
Objectives: Main objective - to compare the clinical effectiveness and cost-effectiveness of thermal ablation versus liver resection surgery in high surgical risk patients who would be eligible for liver resection.
Background: Although surgical resection has been considered the only curative option for colorectal liver metastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment. A prospective randomised trial is required to define the efficacy of resection vs ablation for the treatment of colorectal liver metastases.
Methods: Design and setting: This is a multicentre, open, randomised controlled non-inferiority trial design with internal pilot and will be performed in tertiary liver centres in UK and The Netherlands.