Nebulized isotonic saline improves voice production in Sjögren's syndrome.

Objective: This study examined the effects of a topical vocal fold hydration treatment on voice production over time.

Study Design: Prospective, longitudinal, within-subjects A (baseline), B (treatment), A (withdrawal/reversal), B (treatment) experimental design.

Methods: Eight individuals with primary Sjögren's syndrome (SS), an autoimmune disease causing laryngeal dryness, completed an 8-week A-B-A-B experiment.