Colchicine-induced myoneuropathy mimicking polyradiculoneuropathy.

We report a patient with colchicine-induced myoneuropathy. Myoneuropathy is an under-recognized complication of colchicine. The weakness seen in our patient improved fairly rapidly after discontinuation of colchicine.

Validation of a score tool for measurement of histological severity in juvenile dermatomyositis and association with clinical severity of disease.

Objectives: To study muscle biopsy tissue from patients with juvenile dermatomyositis (JDM) in order to test the reliability of a score tool designed to quantify the severity of histological abnormalities when applied to biceps humeri in addition to quadriceps femoris. Additionally, to evaluate whether elements of the tool correlate with clinical measures of disease severity.

Methods: 55 patients with JDM with muscle biopsy tissue and clinical data available were included.