Term Labor Outcomes after Cerclage Placement in a Multi-institutional Cohort.

Objective: The placement of a cervical cerclage in early pregnancy could influence subsequent labor outcomes at term. Prior studies have yielded conflicting results regarding the potential association with adverse labor outcomes such as cesarean delivery (CD), cervical laceration, and prolonged labor. Our objective was to evaluate rate of CD and adverse maternal outcomes in women who labored at term with and without a cerclage within the Consortium on Safe Labor (CSL) cohort.

Cervical ripening balloon with and without oxytocin in multiparas: a randomized controlled trial.

Background: The optimal method for induction of labor for multiparous women with an unfavorable cervix is unknown.

Objective: We sought to determine if induction of labor with simultaneous use of oxytocin and a cervical ripening balloon, compared with sequential use, increases the likelihood of delivery within 24 hours in multiparous women.

Study Design: We performed a randomized controlled trial from November 2014 through June 2017.

Pregnancy Outcomes after Endometrial Ablation in a Multi-institutional Cohort.

Objective: The objective of this study was to determine the incidence of morbidly adherent placenta in pregnancies after endometrial ablation.

Study Design: We performed a retrospective cohort analysis using a large, multiinstitutional deidentified clinical database, IBM EPM: Explore (IBM Corporation, Somers, NY). We identified women who underwent endometrial ablation and had a subsequent delivery between 1999 and 2016.

History of cervical insufficiency increases the risk of pelvic organ prolapse and stress urinary incontinence in parous women.

Objective: A likely contributor to pelvic floor disorders is injury and degradation of connective tissue components such as collagen and elastin, leading to weakening of the pelvic floor. Prior studies have found similar connective tissue component changes in women with cervical insufficiency (CI). However, the connection between pelvic floor disorders and cervical insufficiency has not previously been evaluated.

Interactions between mecamylamine and alcohol in Long-Evans rats: flash-evoked potentials, body temperature, behavior, and blood alcohol concentration.

Mecamylamine, a noncompetitive antagonist of nicotinic acetylcholine receptors, has many potential clinical applications, including treating alcohol dependency. However, little is known about the combined effects of mecamylamine and alcohol on visual system electrophysiology. We examined the separate and combined effects of mecamylamine (4.