Publications by authors named "Alison Larrea-Alvarado"
Objectives: Hypertensive disorders of pregnancy (HDP) exert a heavy mortality burden in low- to middle-income countries (LMIC). ACOG revised HDP diagnostic guidelines to improve identifying pregnancies at greatest risk but whether they are used in LMIC is unknown.
Study Design: We held a workshop to review ACOG guidelines in La Paz, Bolivia (BO) and then reviewed prenatal, labor and delivery records for all HDP diagnoses and twice as many controls at its three largest delivery sites during the year before and the nine months after a workshop (n = 1376 cases, 2851 controls during the two periods).
Article Synopsis
- The study investigates the effects of high altitude on maternal cardiovascular function and its association with fetal growth restriction (FGR) during the last trimester of pregnancy in La Paz, Bolivia.
- Findings indicate that mothers experiencing FGR showed reduced cardiac output, increased systemic vascular resistance, and higher levels of maternal sFlt1 compared to controls, pointing to impaired cardiovascular performance.
- The results suggest that monitoring maternal cardiovascular function could help identify high-risk pregnancies at high altitudes and improve resource allocation to prevent negative outcomes for both mothers and infants.
Background: Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal death in low- to middle-income countries (LMIC). The American College of Obstetricians and Gynecologists (ACOG) updated diagnostic guidelines to align signs and symptoms with those associated with maternal death. We performed an observational study to ask whether ACOG guidelines were employed and associated with adverse outcomes in La Paz-El Alto, Bolivia, an LMIC.
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