Publications by authors named "Alison Klint"

Article Synopsis
  • Pragmatic clinical trials, like the Diuretic Comparison Project (DCP), aim to lessen the burden on patients and staff while promoting a learning healthcare system, with telephone consent reducing clinical staff workload.
  • The DCP focused on comparing the effectiveness of two diuretics in elderly patients, but faced challenges with telephone consent that required continuous adjustments from the study team.
  • By highlighting the technical and operational obstacles encountered, the DCP provides valuable lessons for future trials, enabling a more efficient telephone consent process going forward.
View Article and Find Full Text PDF

Introduction: The COVID-19 pandemic had significant impact on clinical care and clinical trial operations, but the impact on decentralized pragmatic trials is unclear. The Diuretic Comparison Project (DCP) is a Point-of Care (POC) pragmatic trial testing whether chlorthalidone is superior to hydrochlorothiazide in preventing major cardiovascular (CV) events and non-cancer death. DCP utilized telephone consent, data collection from the electronic health record and Medicare, forwent study visits, and limited provider commitment beyond usual care.

View Article and Find Full Text PDF

Background: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear.

Methods: In a pragmatic trial, we randomly assigned adults 65 years of age or older who were patients in the Department of Veterans Affairs health system and had been receiving hydrochlorothiazide at a daily dose of 25 or 50 mg to continue therapy with hydrochlorothiazide or to switch to chlorthalidone at a daily dose of 12.5 or 25 mg.

View Article and Find Full Text PDF

Background: Recent US guidelines recommend chlorthalidone over other thiazide-type diuretics for the treatment of hypertension based on its long half-life and proven ability to reduce CVD events. Despite recommendations most clinicians prescribe hydrochlorothiazide (HCTZ) over chlorthalidone (CTD). No randomized controlled data exist comparing these two diuretics on cardiovascular outcomes.

View Article and Find Full Text PDF