Publications by authors named "Alison Gillard"
Article Synopsis
- Asthma is linked to airway inflammation and structural changes, and the role of ADAM28, a protein expressed in certain immune cells, in this condition is being explored.* -
- In experiments with mice, those lacking ADAM28 showed less airway responsiveness and reduced airway remodeling features, suggesting ADAM28 exacerbates asthma symptoms.* -
- The study provides evidence that ADAM28 influences airway remodeling and the immune response in asthma, indicating its potential importance in asthma pathophysiology.*
Background: Air pollution, including particulates and gazes such as ozone (O), is detrimental for patient's health and has repeatedly been correlated to increased morbidity and mortality in industrialised countries. Although studies have described a link between ambient particulate matter and increased lung cancer morbidity, no direct relation has yet been established between O exposure and metastatic dissemination to lungs.
Objectives: To outline the mechanisms through which pulmonary O exposure modulates metastasis kinetics in an experimental mouse model of O exposure.