Sedation and memory: studies with a histamine H-1 receptor antagonist.

The influence of sedation on the effect of an H-1 receptor antagonist on various cognitive functions, including memory, were evaluated. Diphenhydramine (50, 75 and 100 mg) and lorazepam (0.5 and 1.

Studies on performance and sleepiness with the H1-antihistamine, desloratadine.

Introduction: The purpose of this study was to establish whether the H1-antihistamine desloratadine (5 mg), the active metabolite of loratadine, is free of effects on performance and sleepiness.

Method: Effects of desloratadine (5 mg) on psychomotor performance, daytime sleep latencies, subjective sleepiness, and memory were studied in nine healthy volunteers (four men, five women) between the ages of 20 and 39 yr (mean 28.2).