Publications by authors named "Alison Conway Fitzgerald"
Background/objective: Diabetic ketoacidosis (DKA) during pregnancy is an obstetric emergency associated with a higher rate of maternofetal morbidity and mortality. Pregnancy itself is a ketosis-prone state and several unique mechanisms predispose to the development of insulin resistance, which can be further exacerbated by acute stressors such as infection. Thus, pregnant patients who additionally contract COVID-19 may be at an even higher risk of development of DKA.
View Article and Find Full Text PDFObjective: To characterize gynecology clinical trials over time, compare gynecology subspecialties, and analyze factors associated with early discontinuation, results reporting, and publication.
Methods: We conducted a cross-sectional analysis of all gynecology trials registered on ClinicalTrials.gov between 2007 and 2020 and their resulting publications.
Article Synopsis
- The research highlights a significant underrepresentation of obstetrical complications in clinical trials, with only 1.9% (4,276) of the 332,417 studies on ClinicalTrials.gov focusing on obstetrics, despite affecting over a third of women worldwide.* -
- The study analyzes various factors related to trial outcomes, specifically examining the impact of funding sources (industry, U.S. government, academic) and trial features on early discontinuation and results reporting.* -
- Results indicate that obstetrical trials are more likely to be discontinued early compared to non-obstetrical trials, with a greater risk factor identified for these trials and a steady annual increase in obstetrical trial registrations over time.*