Publications by authors named "Alison C Leslie"
Article Synopsis
- Schizophrenia (SCZ) shows significant genetic heritability, but specific genetic risk variants are not well understood; classifying SCZ into distinct endophenotypes may help identify these variants.
- The study presents 17 individuals with SCZ-related characteristics and shared brain imaging findings, revealing classic psychiatric features alongside new neuropsychiatric traits like decreased IQ, memory issues, and attention deficits.
- Imaging results showed a consistent pattern of posterior vermis predominant cerebellar hypoplasia, suggesting a potential endophenotype of SCZ rather than Dandy-Walker malformation, although specific genetic variants remain to be identified.
Childhood-onset schizophrenia (COS) is a rare and severe form of schizophrenia with an estimated prevalence of 1/10,000. Schizophrenia and Autism spectrum disorder (ASD) have shared phenotypic features and shared genetic etiology. There is growing research surrounding the co-occurrence of psychomotor syndromes like catatonia with neurodevelopmental disorders like ASD or psychiatric disorders like schizophrenia.
View Article and Find Full Text PDFSuccessful cryoablation of junctional ectopic tachycardia is feasible in a 13.4kg, 18-month-old toddler.
Indian Pacing Electrophysiol J
June 2022
JET (junctional ectopic tachycardia) is a complicated and rare form of supraventricular tachycardia that is associated with a high rate of morbidity and mortality. Pharmaceutical management can be insufficient, and cryoablation has been described for congenital JET management. We describe cryoablation for congenital JET in an prior 32-week gestational aged, 18-month-old (corrected 16-month-old) with no JET post-ablation with normal Holter and follow-up within 6 months following cryoablation.
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