Mechanical ventilation after lung transplantation. An international survey of practices and preferences.

Rationale: Between 10% and 57% of lung transplant (LTx) recipients develop primary graft dysfunction (PGD) within 72 hours of LTx. PGD is clinically and histologically analogous to the acute respiratory distress syndrome. In patients at risk for or with acute respiratory distress syndrome, lung-protective ventilation strategies (low tidal volume and positive end-expiratory pressure) improve outcomes.

Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.

Background: Disrupted HCO3(-) transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF.

Methods: In neonates with and without CF, we measured pH of nasal ASL.