Publications by authors named "Alison A Kitajewski"
Article Synopsis
- - Infantile hemangioma (IH) is a type of vascular tumor that rapidly grows after birth and shrinks during early childhood, with NOTCH3 playing a key role in the differentiation of stem cells involved in this process.
- - NOTCH3 is found in both hemangioma stem cells (HemSCs) and endothelial cells during the proliferative phase of IH, but its expression shifts to mural cells in the involution phase.
- - Inhibition of NOTCH3 in HemSCs disrupts the normal development of mural cells and vascular stability, indicating its critical role in the differentiation and maintenance of blood vessels in IH.
Unlabelled: Infantile hemangiomas (IHs) are the most common vascular tumor and arise from a hemangioma stem cell (HemSC). Propranolol has proved efficacious for problematic IHs. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist that can lower cAMP levels and activate the mitogen-activated protein kinase (MAPK) pathway downstream of βARs.
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