Finding epitopes of outer membrane protein-K17 (OMPK17) and introducing a 25-mer peptide of it as a vaccine candidate.

Unlabelled: No approved vaccine exists for yet. Outer membrane protein-K17 (OMPK17) is involved in pathogenesis. No information has been found about OMPK17 dominant epitopes in the literature.

Comparison of Therapeutic Effect and Safety of Oral and Rectal Use of Acetaminophen on Patent Ductus Arteriosus in Preterm Infants: Clinical Randomized Trial.

The prevalence of patent ductus arteriosus (PDA) in preterm infants is high. There is little information about the therapeutic effect and safety of rectal acetaminophen in the treatment of PDA. We aimed to compare the therapeutic effect and safety of oral and rectal acetaminophen on PDA in preterm infants.

Prevention of mother-to-child transmission of HIV in Kermanshah, west of Iran from 2014 to 2021.

Background: This study aimed to evaluate the implementation of the prevention of mother-to-child transmission (PMTCT) of the HIV-PMTCT program in Kermanshah, west of Iran, from 2014 to 2021.

Methods: The data of all HIV-infected mothers and their infants who were monitored by the Kermanshah behavioral diseases counseling center was extracted and recorded in a checklist.

Results: Out of 95 included infant, 45 (47.

Prevalence of Antibiotic-Resistant Lactobacilli in Sepsis Patients with Long-Term Antibiotic Therapy.

Lactobacilli are the most common probiotic bacteria found in the human gut microbiota, and the presence of acquired antibiotic resistance determinants carried on mobile genetic elements must be screened due to safety concerns. Unnecessary and inappropriate antibiotic therapy, as well as ingested antibiotic resistance bacteria (originating from food or food products), influence the abundance of antibiotic resistance genes in human guts, with serious clinical consequences. The current study looked into the antibiotic resistance of lactobacilli isolated from the guts of sepsis patients on long-term antibiotic therapy.

Survival-related factors in HIV/AIDS patients: A retrospective cohort study from 2011 to 2019 in Kermanshah, Iran.

Introduction: Accurate evaluation of the survival rate among HIV-positive populations is pivotal for HIV management.

Objective: This study aimed to investigate the survival rate and potential survival-related factors in HIV/AIDS patients from 2011 to 2019 in the city of Kermanshah in the west of Iran.

Method: In this study, 915 HIV-positive patients registered by the Kermanshah Behavioral diseases counseling center, were surveyed from 2011 to 2019.

A systematic review and meta-analysis on the antibiotic resistance of Neisseria meningitidis in the last 20 years in the world.

Background: Neisseria meningitidis is one of the most important causes of meningitis and pathogens-associated deaths in developing and developed countries. Effective anti-microbial agents are pivotal to treat and control N. meningitidis infections.

Clinical manifestations, associated diseases, diagnosis, and treatment of human infections caused by : a systematic review.

Introduction: is a bacillus that can cause cutaneous and systemic diseases in humans. Studies on the infection caused by this bacterium have been mostly done as case reports. This study aimed to systematically review infection cases published over the last 20 years.

A systematic review and meta-analysis of Listeria monocytogenes isolated from human and non-human sources: the antibiotic susceptibility aspect.

Listeria monocytogenes causes listeriosis with a high mortality rate. This study systematically reviewed the antibiotic susceptibility of L. monocytogenes in the world.

Detecting the Dominant T and B Epitopes of Ferric Enterobactin Protein (FepA) and Introducing a Single Epitopic Peptide as Vaccine Candidate.

Unlabelled: causes various human infections. Ferric enterobactin protein (FepA) is a conserved protein of with high immunogenicity. In the present study, using comprehensive in silico approaches the T and B cell-specific epitopes of FepA were identified.

The effects of natural disasters on leishmaniases frequency: A global systematic review and meta-analysis.

Objectives: Natural disasters (NDs) may increase the outbreaks and transmissions of vector-borne diseases such as cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). However, the relationship between leishmaniases and NDs has not yet been clearly established. Here, we systematically reviewed all reported articles in this field to answer whether NDs increase the frequency of leishmaniases.

B Cell Epitopes of Four Fimbriae Antigens of : A Comprehensive In Silico Study for Vaccine Development.

is one of the major causes of nosocomial infections worldwide which can cause several diseases in children and adults. The globally dissemination of hyper-virulent strains of and the emergence of antibiotics-resistant isolates of this pathogen narrows down the treatment options and has renewed interest in its vaccines. Vaccine candidates of have not been adequately protective, safe and globally available yet.

Immunoinformatics and molecular dynamics studies to predict T-cell-specific epitopes of four fimbriae antigens.

() is a causative agent of severe infections in humans. There is no publically available vaccine for infections yet. Here, using comprehensive immunoinformatics methods, T-cell-specific epitopes of four type 1 fimbriae antigens of were predicted and evaluated as potential vaccine candidates.

Antimicrobial Resistance of Isolated from Hospital Wastewater in Kermanshah, Iran.

Introduction: Hospital wastewater contains highly resistant and virulent bacteria that can spread into the environment. This study was conducted to investigate the antimicrobial resistance of methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) in raw and treated hospital wastewater.

Methods: During a three-month period, 40 sewage samples were collected from the hospital sewage (Kermanshah, Iran), and were identified using culture and biochemical tests.

Usefulness of Blood Parameters for Preliminary Diagnosis of Brucellosis.

Background: Human brucellosis is a multisystem disease with a wide range of clinical signs which often leads to misdiagnosis and treatment delay. Early diagnosis of this disease can prevent the serious complications and mismanagements. This study aimed to evaluate the hematological parameters with predictive value for the diagnosis of brucellosis.

Effect of and extracts on and : An study.

Objective: Current therapy strategies of leishmaniasis have some problems such as high cost, toxicity and side effects. Plant extracts can be a source of drugs to control leishmaniasis. In this study, the effect of hydroalcoholic and chloroformic extracts of , and on and was studied.

Identification of HLA-I restricted epitopes in six vaccine candidates of Leishmania tropica using immunoinformatics and molecular dynamics simulation approaches.

In spite of numerous studies on vaccination for various species of Leishmania, research on the development of an effective vaccine for L. tropica is very scarce. In silico epitope prediction is a new way to survey the best vaccine candidates.

Heterogeneity of humoral immune response to Leishmania tropica in an experimental model.

Humoral (antibody) response is an important part of immunity against pathogens. Despite the clear role of cell-mediated immune response in protection against leishmaniasis, the role of humoral responses is challenging. There is very limited data regarding humoral immune response against Leishmania tropica which is the causative agent of human cutaneous leishmaniasis in many parts of the world.

Gene cassettes of class I integron-associated with antimicrobial resistance in isolates of with multidrug resistance.

Background And Objectives: Integrons play a major role in the transmission and accumulation of resistance factors in multidrug resistant bacteria. This study was aimed to evaluate the gene cassettes of class I integron and antimicrobial resistance in isolates of with multidrug resistance (MDR).

Materials And Methods: Ninety isolates of were collected from the largest hospital in Kermanshah, Iran.

Dissemination of Multidrug-Resistant, Class I and II Integrons and Molecular Typing of CTX-M-producing .

Introduction: () is an important opportunistic pathogen causes serious community and hospital-acquired infections, which is highly resistant to antibiotics. We aimed to determine the frequency of multidrug resistant (MDR) and molecular typing of clinical isolates of .

Methodology: One hundred isolates of were collected from clinical samples in three general hospitals in Kermanshah.

The clonal relationship among the isolated from the main hospital in Kermanshah, west of Iran.

Background And Objectives: is an opportunistic pathogen causing nosocomial infections and resistant to various antibiotics. We aimed to determine the clonal relationship of isolates using Pulsed-Field Gel Electrophoresis (PFGE).

Materials And Methods: Fifty clinical isolates of were collected from the main hospital in Kermanshah.

Listeria monocytogenes does not survive ingestion by Acanthamoeba polyphaga.

Listeria monocytogenes is a ubiquitous bacterium capable of infecting humans, particularly pregnant women and immunocompromised individuals. Although the intracellular invasion and pathogenesis of listeriosis in mammalian tissues has been well studied, little is known about the ecology of L. monocytogenes , and in particular the environmental reservoir for this bacterium has not been identified.