Publications by authors named "Alisa Veler"
Article Synopsis
- T cells have multiple inhibitory receptors that can be expressed simultaneously during T cell exhaustion, particularly in response to persistent antigens in cancer.
- Key receptors like CTLA-4, PD-1, LAG3, TIM3, and TIGIT are important targets for cancer immunotherapy, but their subcellular localization varies significantly.
- The study demonstrates that while these receptors reside in overlapping vesicular structures, CTLA-4 has a very distinct localization pattern linked to lysosomal-derived vesicles, suggesting the need for further exploration into their trafficking mechanisms for potential therapeutic applications.
T cells can express multiple inhibitory receptors. Upon induction of T cell exhaustion in response to persistent antigen, prominently in the anti-tumor immune response, many are expressed simultaneously. Key inhibitory receptors are CTLA-4, PD-1, LAG3, TIM3 and TIGIT, as investigated here.
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