Publications by authors named "Alisa Mikhailina"
The Sm and Sm-like proteins are widely distributed among bacteria, archaea and eukarya. They participate in many processes related to RNA-processing and regulation of gene expression. While the function of the bacterial Lsm protein Hfq and eukaryotic Sm/Lsm proteins is rather well studied, the role of Lsm proteins in Archaea is investigated poorly.
View Article and Find Full Text PDFArticle Synopsis
- The paper investigates the formation of Aβ amyloid fibrils using theoretical models and experimental techniques like electron microscopy and X-ray diffraction.
- It determines the sizes of the "nuclei" required to form these fibrils, finding that Aβ42 has a primary nucleus of 3 monomers and a secondary nucleus of 2, while Aβ40 has a primary nucleus of 2 monomers and a secondary nucleus of 1.
- The study proposes a new model for amyloid fibril organization, suggesting that therapy targets should focus on specific oligomer sizes (tetramers for Aβ42 and trimers for Aβ40) to effectively inhibit their formation.