Publications by authors named "Alisa Koivuporras"

Quinic acid (QA) is a cyclic polyol exhibiting anticancer properties on several cancers. However, potential role of QA derivatives against glioblastoma is not well established. Sixteen novel QA derivatives and QA- encapsulated poly (lactic-co-glycolic acid) nanoparticles (QA--NPs) were screened for their anti-glioblastoma effect using standard cell and molecular biology methods.

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The installation of vicinal mesylate and silyl ether groups in a quinic acid derivative generates a system prone for stereoselective borane-catalyzed hydrosilylation through a siloxonium intermediate. The diversification of the reaction conditions allowed the construction of different defunctionalized fragments foreseen as useful synthetic fragments. The selectivity of the hydrosilylation was rationalized on the basis of deuteration experiments and computational studies.

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