Publications by authors named "Alisa Hnatiuk"
While pancreatic beta-cell proliferation has been extensively studied, the role of cell death during islet development remains incompletely understood. Using a genetic model of caspase inhibition in beta cells coupled with mathematical modeling, we here discover an onset of beta-cell death in juvenile zebrafish, which regulates beta-cell mass. Histologically, this beta-cell death is underestimated due to phagocytosis by resident macrophages.
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- Regeneration-competent species, like zebrafish, can reverse severe diseases by restoring damaged tissue, but the cellular mechanisms behind this are not well understood.
- Using single-cell transcriptomics, researchers mapped how zebrafish regenerate β-cells during diabetes recovery, identifying two types of somatostatin-producing δ-cells and glucose-responsive islet cells.
- The study found that β/δ hybrid cells play a crucial role in insulin expression during recovery, and manipulating a specific gene can enhance their formation, highlighting the potential for understanding diabetes resolution.