A Study of Synergy of Combination of Eosin B with Chloroquine, Artemisinin, and Sulphadoxine-Pyrimethamine on and .

Methods: Drug assessment was carried out singly or in combination on using the candle jar method at three inhibitory concentrations. Percent parasitemia of live cells was obtained by microscopic counting. Peter's suppression test was carried out on mice infected with after 3 administration of the drugs singly and in combination, and parasites were counted by microscopy for 10 days.

A Metabolomic Investigation of the Effect of Eosin B on Game-tocyte of 1HNMR Spectroscopy.

Background: Recently eosin B was shown to have an effect on the asexual stage of and in this study, its activity against gametocytes and changes in the culture medium metabolites were investigated using anHNMR-based metabolomics approach.

Methods: In the Biochemistry Department of Pasteur Institute of Iran in 2017, parasites were cultured and gametocytogenesis induced by heparin and 5% hematocrit. Sexual stage parasites were tested by eosin B in 90 well plates and IC determined using Lactate Dehydrogenase assay.

Efficacy of eosin B as a new antimalarial drug in a murine model.

The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro.