Cerium(III) immobilized on the functionalized halloysite as a highly efficient catalyst for aza-Diels-Alder reaction.

Aza-Diels-Alder cycloaddition reaction is a critical synthetic method for the production of bioactive tetrahydroquinolines. To this aim, an imine obtained from the reaction of an aniline derivative and a carbonyl compound is cyclized with an alkene in the presence of a catalyst. In this research, some tetrahydroquinoline compounds are synthesized through aza-Diels-Alder reaction in the presence of a prepared Ce(III) immobilized on the functionalized halloysite (Ce/Hal-TCT-IDA) as a catalyst.

Preparation and application of a new ion-imprinted polymer for nanomolar detection of mercury(II) in environmental waters.

This study introduces a novel ion-imprinted polymer for the ultrasensitive detection of mercury(II) in water. The ion-imprinted polymer was synthesized via a simple bulk polymerization process using methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross-linker, morpholine-4-carbodithioic acid phenyl ester as the chelating agent, and ammonium persulfate as the initiator. The electrochemical mercury(II) sensing capability of the ion-imprinted polymer was studied via the modification of a cost-effective carbon paste electrode.

Palladium doped PDA-coated hercynite as a highly efficient catalyst for mild hydrogenation of nitroareness.

Hercynite magnetic nanoparticles were produced through the co-precipitation of ferrous and aluminum cations. The surface of hercynite was respectively coated with silica, 2,4,6-trichloro-1,3,5-triazine, and 1H-pyrazole-3,5-dicarboxylic acid to provide a suitable substrate for Pd(II) loading, furnishing Pd@Her-TCT-PDA. Subsequently, the introduced Pd(II) was reduced to Pd(0) using NaBH.

Study of the anti-cancer activity of a mesoporous silica nanoparticle surface coated with polydopamine loaded with umbelliprenin.

A mesoporous silica nanoparticle (MSN) coated with polydopamine (PDA) and loaded with umbelliprenin (UMB) was prepared and evaluated for its anti-cancer properties in this study. Then UMB-MSN-PDA was characterized by dynamic light scattering (DLS), Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM) and FTIR methods. UV-visible spectrometry was employed to study the percentage of encapsulation efficiency (EE%).

Investigating the effect of hesperetin on estrogen receptor alpha (ERα) expression, phosphorylation and activity in MCF-7 cells.

Purpose: The most common malignancy among women worldwide is breast cancer. The estrogen receptor plays a vital role in this cancer. One of the most well-known mechanisms that affects the activity of this receptor is its phosphorylation by protein kinase pathways.

Probing the interaction behavior of Nano-Resveratrol with α-lactalbumin in the presence of β-lactoglobulin and β-casein: spectroscopy and molecular simulation studies.

The main purpose of this research was to evaluate the role of α-lactalbumin (α-LA), β-lactoglobulin (β-LG), and β-Caseins (β-CN) in the binding interaction between Nano Resveratrol (Nano Res), as binary and ternary systems. This investigation was fulfilled through the application of multi-spectroscopic, transmission electron microscopy (TEM), field emission scanning electron microscope (FE-SEM), conductometry, isothermal titration calorimetry (ITC), and molecular dynamics (MD) simulation techniques. Fluorescence spectroscopy observations illustrated the effectiveness of Nano Res throughout the quenching of α-LA, (α-LA-β-LG), and (α-LA-β-CN) complexes, confirming the occurrence of interaction through the combination of static and dynamic mechanisms.

Green synthesis of zinc and nickel dual-doped cerium oxide nanoparticles: antioxidant activity and cytotoxicity effects.

Cerium oxide nanoparticles (CeO-NPs) and Zn-Ni dual-doped CeO-NPs were synthesized through a green approach by the implication of zucchini peel (Cucurbita pepo) extract as a capping and reduction agent. All the synthesized samples were studied by the results of FTIR, UV-Vis, XRD, and FESEM/EDAX/PSA analyses. The Zn-Ni dual-doped CeO-NPs contained a spherical morphology and their size was observed to increase at higher temperatures.

Green synthesis of cerium oxide nanoparticles using zucchini peel extract for cytotoxic and photocatalytic properties.

The aim of this study is the green synthesis of cerium oxide nanoparticles (CeO-NPs) using a natural capping agent and its application in water and wastewater treatment. This study presents the biosynthesis of CeO-NPs by the exertion of a green method using zucchini (Cucurbita pepo) extract as a capping agent. Synthesized CeO-NPs were distinguished through TGA/DTA, FT-IR, XRD, FESEM/TEM and EDX/PSA, and DRS procedures.

Urolithin B loaded in cerium oxide nanoparticles enhances the anti-glioblastoma effects of free urolithin B in vitro.

Glioblastoma multiforme (GBM) is the most aggressive kind of malignant primary brain tumor in humans. Given the limitation of Conventional therapeutic strategy, the development of nanotechnology and natural product therapy seems to be an effective method enhancing the prognosis of GBM patients. In this research, cell viability, mRNA expressions of various apoptosis-related genes apoptosis, and generation of reactive oxygen species (ROS) in human U-87 malignant GBM cell line (U87) treated with Urolithin B (UB) and CeO-UB.

Clinical significance of TRIM29 expression in patients with gastric cancer.

Aim: The present study aimed to evaluate the expression profile, prognostic value, and possible correlation of TRIM29 with β-catenin, Cyclin D, and Bcl2 in Iranian patients with GC.

Background: Tripartite Motif Containing 29 (TRIM29) has been reported to function as an oncogene or a tumor suppressor depending on the tumor type. This contextual function has created a controversial situation that needs to be fully delineated in various cancers.

Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.

Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine. However, most of the designed filament vehicles hold weak mechanical properties, which hinder their applications in specific tissue engineering. We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.

Inflammatory, oxidative stress and cognitive functions in patients under maintenance treatment with methadone or buprenorphine and healthy subjects.

Background: Methadone and buprenorphine which are widely used for opioid maintenance treatment can affect redox status and also brain functions. The present study aimed to compare inflammation, oxidative stress, and cognitive function in methadone maintenance patients (MMP), buprenorphine maintenance patients (BMP), and healthy participants.

Method: Oxidative- antioxidant markers, inflammatory factors were investigated in MMP (n = 30), BMP (n = 30), and healthy participants (n = 30) by evaluating the ferritin, malondialdehyde (MDA), total antioxidant capacity (TAC), and also High-sensitivity C-reactive protein (hs-CRP).

ZnO nanoparticles supported on dendritic fibrous nanosilica as efficient catalysts for the one-pot synthesis of quinazoline-2,4(1,3)-diones.

The transmutation of waste into valuable materials has a special place in green chemistry. Herein, we report the preparation of quinazoline-2,4(1,3)-diones from 2-iodoaniline, isocyanides, and carbon dioxide in the presence of ZnO NPs stably placed on the surface of dendritic fibrous nanosilica by cellulose (DFNS/cellulose-ZnO) as a catalyst. This is a great economic strategy to create three bonds in a one-pot multicomponent reaction step employing functional groups.

Sulfated zirconium oxide-decorated magnetite KCC-1 as a durable and recyclable adsorbent for the efficient removal of asphaltene from crude oil.

Sulfated zirconium oxide (ZrO/SO ) as a highly durable acidic reagent was immobilized on magnetite KCC-1 nanoparticles (FeO@SiO/KCC-1@ZrO/SO NPs), and the resulting hybrid was used as a highly efficient recyclable adsorbent for the adsorption and removal of asphaltene from crude oil. The presence of ZrO/SO groups not only promotes the adsorption capacity, but also helps recycle the adsorbents without any significant efficiency loss arising from its high chemical resistance. The results showed an obvious synergistic effect between the magnetic core (FeO NPs), fibrous silica (KCC-1) and the sulfated zirconium oxide groups with high correlation for asphaltene adsorption.

Olive oil-based quercetin nanoemulsion (QuNE)'s interactions with human serum proteins (HSA and HTF) and its anticancer activity.

The current study produced Quercetin nanoemulsions (QuNEs) for the purpose of improving Quercetin solubility in an aqueous polar condition and to analyze QuNE-protein formation (QuNE-human serum albumin (HSA) and QuNE-holo-transferrin (HTF)).QuNE was produced by utilizing an ultrasound-based emulsification method and was characterized by DLS, TEM, and SEM. Its interaction with HSA and HTF proteins was studied by analyzing the results of FRET and RLS spectroscopy, Stern-Volmer plotting, the Van't Hoff equation, CD spectroscopy, and molecular docking methods.

In silico profiling and structural insights of zinc metal ion on O6-methylguanine methyl transferase and its interactions using molecular dynamics approach.

O6-methylguanine DNA methyl transferase (MGMT) is a metalloenzyme participating in the repair of alkylated DNA. In this research, we performed a comparative study for evaluating the impact of zinc metal ion on the behavior and interactions of MGMT in the both enzymatic forms of apo MGMT and holo MGMT. DNA and proliferating cell nuclear antigen (PCNA), as partners of MGMT, were utilized to evaluate molecular interactions by virtual microscopy of molecular dynamics simulation.

Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.

Background/aims: Tripartite motif-containing 3 (TRIM3) is a member of the TRIM protein family which is known to be involved in development of numerous tumor types. However, the prognostic role of TRIM3 in gastric cancer (GC) remained to be clarified. The aim of this study was to evaluate the expression pattern and prognostic significance of TRIM3 gene and its relationship with β-catenin, CyclinD, and BCL2 expression in patients with GC.

Synthesis and characterization of a novel TEMPO@FeNi/DFNS-laccase magnetic nanocomposite for the reduction of nitro compounds.

Water is an essential substance for life on earth and for all living things. Plants and animals need almost pure water to live; if it is contaminated with harmful chemicals and micro organisms, it will be impossible for them to survive. This study has tried to investigate the performance of catalyst to reduce nitro-aromatic combinations in the attendance of NaBH solution duo to the hydrogen source.

FeNi magnetic nanoparticles supported on ruthenium silicate-functionalized DFNS for photocatalytic CO reduction to formate.

For aerobic oxidation, anchoring ruthenium(ii) in the nanospaces of magnetic dendritic fibrous nanosilica (DFNS) afforded a potential nanocatalyst (the complex FeNi/DFNS/Ru(ii)), which showed enhanced activity. The FeNi/DFNS/Ru(ii) complex exhibited excellent catalytic activity in the reduction of carbon dioxide to formate in the presence of visible-light irradiation. We have analyzed its characteristics by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), a vibrating sample magnetometer (VSM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA).

A new class of organoplatinum-based DFNS for the production of cyclic carbonates from olefins and CO.

We studied the potential application of an efficient, reusable, and easily recoverable catalyst of dendritic fibrous nanosilica (DFNS)-supported platinum(ii) complexes (DFNS/Pt(ii) NPs) to form cyclic carbonates in the presence of epoxides by converting carbon dioxide. Cyclic carbonates from epoxides and carbon dioxide is proposed as the most appropriate way to synthesis this C1 building block. We performed FE-SEM, TEM, TGA, BET, VSM, and ICP-MS to thoroughly characterize DFNS/Pt(ii) NPs.

Synthesis and characterization of a novel CNT-FeNi/DFNS/Cu(ii) magnetic nanocomposite for the photocatalytic degradation of tetracycline in wastewater.

Herein, Cu(ii) complexes were anchored within the nanospaces of a magnetic fibrous silicate with a high surface area and easily accessible active sites a facile approach, leading to the successful synthesis of a novel potent nanocatalyst (FeNi/DFNS/Cu). Furthermore, FeNi/DFNS/Cu was supported on carbon nanotubes (CNTs) an usual nozzle electrospinning method (CNT-FeNi/DFNS/Cu). In addition, its performance as a photocatalyst for the degradation of tetracycline was tested in a batch reactor.