Immunomodulatory activities of chitin microparticles on Leishmania major-infected murine macrophages.

Background: Chitin microparticles (CMPs) are found to be potent macrophage stimulators; however, their immunomodulatory effects on the parasite-infected macrophages have not yet been studied. To address this issue, we used a Leishmania major-infected murine macrophage model and characterized the regulatory effects of CMPs on the parasite-infected cells.

Methods: Mouse peritoneal macrophages were prepared and infected with L.