Publications by authors named "Alireza Meighani"

Background: Fecal microbiota transplantation (FMT) is a well-established therapeutic option for patients with antibiotic resistant infection (CDI). However, the efficacy of FMT in patients with chronic liver disease remains elusive.

Aims: We studied the effect of FMT on chronic liver disease (CLD) patients with CDI at our tertiary medical center.

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Chronic hepatitis C virus infection (HCV) can present with cryoglobulinemic vasculitis, which is primarily associated with type II/III cryoglobulins. Type I cryoglobulins are usually seen in lymphoproliferative disease, and large vessel involvement with this type of vasculitis is rare. A 70-year-old man with chronic HCV presented with abdominal pain, leukocytosis, and rash.

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Background And Aims: Fecal microbiota transplantation (FMT) has recently been shown to be a promising therapy for recurrent and refractory Clostridium difficile infections (CDI) despite lack of protocol standardization. Patients with inflammatory bowel disease (IBD) present a particular challenge to CDI therapy as they are reported to have worse clinical outcomes, including higher colectomy rates and increased mortality. We aimed to assess the outcomes of FMT for recurrent CDI in patients with IBD at our healthcare system.

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Zollinger-Ellison syndrome (ZES) is a rare clinical disorder, characterized by hypersecretion of gastric acid and multiple ulcers distal to the duodenal bulb. This occurs via the release of gastrin by neuroendocrine tumors known as gastrinomas. Patients with ZES present with nonspecific GI symptoms, which often leads to a delay in diagnosis.

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Post-transplantation refractory ascites is uncommon; however, it can be a serious problem, increasing both morbidity and mortality in patients. Despite scant literature available, splenic artery embolization (SAE) has been shown to be an effective treatment for refractory ascites after cadaveric orthotopic liver transplantation (OLT). We report a successful use of therapeutic SAE for refractory ascites post-OLT.

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Article Synopsis
  • Clostridium difficile infection (CDI) poses significant healthcare challenges, but fecal microbiota transplantation (FMT) shows a much higher success rate (80-90%) compared to traditional antibiotic treatments for recurrent cases.
  • In a study of 201 patients undergoing FMT, the failure rate was 12.4%, with predictors of failure including being female, previous hospitalizations, and surgeries before the transplant.
  • The overall mortality rate was 9.0%, and failure of FMT significantly increased the risk of death, emphasizing the need for awareness of risk factors associated with FMT outcomes.
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