Effect of surgical flap on IL-1β and TGF-β concentrations in the gingival crevicular fluid of patients with moderate to severe chronic periodontitis.

Background: Growth factors play a major part in wound healing in many tissues including the periodontium. Transforming growth factor-β1 (TGF-β1) is one of these factors present in the gingival crevicular fluid. In addition, it is considered as one of the most important anti-inflammatory cytokines.