Melatonin in the Management of Mood and Sleep Problems Induced by Androgen Deprivation Therapy in Prostate Cancer Patients: A Randomized Double-blinded, Placebo-controlled Clinical Trial.

Background: Androgen deprivation therapy (ADT) has been considered as a mainstay of treatment for advanced prostate cancer. Considering ADT for cancer patients is accompanied with many side effects, such as behavioral and neurologic side effects that adversely affect the quality of life.

Objectives: This study aimed to evaluate the effects of melatonin administration on sleep problems and mood changes induced by ADT in prostate cancer patients.

A high school-based education concerning drug abuse prevention.

Objective: There is increasing evidence for declining the onset age of drug abuse worldwide. This study was conducted to investigate the effectiveness of four educational methods including lecture, presentation of poster and leaflet, presentation of video clip, and group/class discussion for life skills training and changing in knowledge and attitude of adolescents toward drug abuse.

Materials And Methods: In a pretest-posttest design, a sample of 897 girl and boy high school students from the first grade (14-15 years old) were involved in this cross-sectional study conducted in Isfahan, Iran.