Neuroinflammation Co-localizes Highly with Tau in Mild Cognitive Impairment from Early Onset Alzheimer's Disease (N4.002).

Objective: To study neuroinflammation in early-onset Alzheimer's disease (AD) and its brain topography, compared with that of tau and amyloid.

Background: Neuroinflammation is a potential therapeutic target in AD. Translocator protein (TSPO) positron emission tomography (PET) is useful to image neuroinflammation, but most "second generation" inflammation tracers cannot image subjects with a low-binder rs6971 genotype.