Publications by authors named "Aliona Debisschop"
Article Synopsis
- * The review discusses using cationic amphiphilic drugs (CADs) to improve the escape of NAs from endosomes, as they can disrupt cellular membranes and change endosomal pathways.
- * Repurposing existing CADs, which are commonly used medications, could enhance combination therapies with nucleic acid drugs, potentially increasing their effectiveness.
The delivery of RNA across biological barriers can be achieved by encapsulation in lipid nanoparticles (LNPs). Cationic amphiphilic drugs (CADs) are pharmacologically diverse compounds with ionizable lipid-like features. In this work, we applied CADs as a fifth component of state-of-the-art LNPs via microfluidic mixing.
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