Publications by authors named "Aline da Silva Justo"
J Ethnopharmacol
September 2016
Article Synopsis
- Euphorbia umbellata, commonly known as leitosinha, is traditionally used in southern Brazil for gastric issues and offers analgesic and anti-inflammatory benefits.
- A study examined the anti-ulcer effects of a methanolic bark fraction (MF), assessing its activity both in lab settings (in vitro) and with live subjects (in vivo), focusing on antioxidant and antibacterial properties.
- Results indicated that MF effectively reduced ulcers in animal models, exhibited strong antioxidant properties, and showed potential mechanisms like prostaglandin pathways and glutathione involvement, supporting its traditional use in folk medicine.
J Ethnopharmacol
May 2016
Article Synopsis
- Euphorbia umbellata latex has been used traditionally in southern Brazil to treat cancers, prompting a study to investigate its effectiveness and mechanisms of action.
- The research involved testing various fractions of the latex on cancer cell lines using multiple assays, revealing that the hexane fraction was the most toxic, particularly to Jurkat cells, and that it caused DNA fragmentation and apoptosis.
- A phytochemical analysis isolated compounds like euphol and germanicol acetate from the hexane fraction, which showed some cytotoxic activity, but it was still lower than that of the standard cancer drug vincristine.
