Synthesis and physico-chemical properties of the first water soluble Cu(ii)@hemicryptophane complex.

A hemicryptophane ligand soluble in water at neutral pH was obtained thanks to the derivatization of the cyclotribenzylene unit with three carboxylate groups. The corresponding Cu(ii) complex was then synthesized and its spectroscopic and electrochemical properties in water were investigated, showing that water solubilisation retains the geometry of the complex around the metal center but strongly affects its redox properties, compared to previously reported Cu(ii)@hemicryptophane complexes soluble in organic solvents.

Improved hemicryptophane hosts for the stereoselective recognition of glucopyranosides.

Four new enantiomerically and diastereomerically pure hemicryptophane hosts (M-SSS-2/P-SSS-2 and M-RRR-2/P-RRR-2 pairs) were designed for the recognition of sugar derivatives. Their absolute configuration was determined from the circular dichroism spectra and DFT calculations. The host molecules were then used for the stereoselective recognition of glucopyranosides.

Synthesis of the first water-soluble hemicryptophane host: selective recognition of choline in aqueous medium.

The first water-soluble hemicryptophane cage compound, 4, was synthesized in seven steps from commercially available products, and its complexation properties were studied. NMR and ITC experiments indicate that 4 is an efficient receptor for choline in water (ΔG° = -5.2 kcal mol(-1)).

Synthesis of cyclic peptide hemicryptophanes: enantioselective recognition of a chiral zwitterionic guest.

The synthesis of the first members of a new class of cyclic peptide-containing hemicryptophanes is described. Synthesis was achieved through attachment of veratryl groups to the L-tyrosine side chains of a cyclic hexapeptide, c(YG)3, followed by intramolecular cyclodehydration to generate the CTV unit. The diastereomeric P- and M-hemicryptophanes were generated in a 2 : 1 ratio and were separated by chromatography.

Chiral discrimination of ammonium neurotransmitters by C₃-symmetric enantiopure hemicryptophane hosts.

Enantiopure hemicryptophanes efficiently discriminate chiral ammonium neurotransmitters. The ephedrine and norephedrine molecules associate with hemicryptophane hosts to form 1:1 and 1:2 host-guest complexes. Binding constants are determined by fitting the ¹H nuclear magnetic resonance (NMR) titration curves to give β₁ and β₂ values, which are used to characterize the diastereomeric and enantiomeric discriminating potentials of the hosts.

[Epidemiologic investigation into characteristics of canine and feline population in a district close to a rural area in Cuiabá-MT, with a view to control of animal rabies].

Questionnaires answered by 476 students (age 15-20 yrs) attending a local school in the neighborhood of Pedra 90 in Cuiabá -MT were analyzed in order to study the characteristics of feline and canine populations in the region. The results showed that 371 (78%) of the 476 families kept 513 dogs and 307 cats. Of 573 dogs, 289 (56.