Publications by authors named "Aline Rodrigues-Prause"
Characterization of systemic genomic instability in budding yeast.
Nadia M V Sampaio V P Ajith Ruth A Watson Lydia R Heasley Parijat Chakraborty Aline Rodrigues-Prause
Proc Natl Acad Sci U S A
November 2020
Conventional models of genome evolution are centered around the principle that mutations form independently of each other and build up slowly over time. We characterized the occurrence of bursts of genome-wide loss-of-heterozygosity (LOH) in , providing support for an additional nonindependent and faster mode of mutation accumulation. We initially characterized a yeast clone isolated for carrying an LOH event at a specific chromosome site, and surprisingly found that it also carried multiple unselected rearrangements elsewhere in its genome.
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- The strain JAY270/PE2 is a powerful yeast used for bioethanol production from sugarcane, known for its non-aggregation property which aids in cell recycling during fermentation.
- The strain faces potential genomic instability over time, leading to issues such as cell aggregation and defects in mother-daughter cell separation, resulting in observable rough colonies.
- Investigating these changes revealed that the instability rates in JAY270 are similar to those in conventional lab strains, highlighting that genomic dynamics in this industrial yeast strain are typical rather than excessively unstable.