Publications by authors named "Aline Melro Murad"
Article Synopsis
- Humanity faces a growing health crisis due to multidrug resistant bacteria, particularly MRSA, which causes many hospital infections.
- Identifying new treatment strategies is crucial, focusing on analyzing the structure and function of key bacterial enzymes like SaDHNA in the vitamin K synthesis pathway.
- Researchers have determined the crystal structure of SaDHNA and found important amino acids for its activity, laying the groundwork for developing drugs that inhibit this enzyme.
Trypsin inhibitors from tamarind seed have been studied and in preclinical studies for the treatment of obesity, its complications and associated comorbidities. It is still necessary to fully understand the structure and behaviour of these molecules. We purifed this inhibitor, sequenced by MALDI-TOF/TOF, performed its homology modelling, and assessed the interaction with the trypsin enzyme through molecular dynamics (MD) simulation under physiological conditions.
View Article and Find Full Text PDFSugarcane (Saccharum spp.) is the world most productive sugar producing crop, making an understanding of its stress physiology key to increasing both sugar and ethanol production. To understand the behavior and salt tolerance mechanisms of sugarcane, two cultivars commonly used in Brazilian agriculture, RB867515 and RB855536, were submitted to salt stress for 48 days.
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