Publications by authors named "Aline J Charabaty"
Article Synopsis
- - The use of immune checkpoint inhibitors (ICI) in treating cancers presents a challenge due to the balance between achieving long-lasting remissions and managing autoimmune-like side effects.
- - A specific case involved a patient with widespread uveal melanoma who responded remarkably to ipilimumab and nivolumab but suffered serious side effects, including vision issues and gastrointestinal problems.
- - TCR-sequencing revealed that the same T cell clone was present in the primary tumor, a metastasis, and other body tissues, suggesting that cross-reactivity may explain the connection between the effectiveness and toxicity of ICIs.
Although ipilimumab has been shown to improve survival in patients with metastatic melanoma and cause regression of metastatic renal cell carcinoma, the associated immune-related toxicities are of concern. The resultant T cell activation by this monoclonal antibody causes an increased immune response, which has been associated with many immune-regulated adverse effects. One of the most concerning effects is the development of colitis.
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