Publications by authors named "Aline Horling"
Article Synopsis
- - Ferroptosis is a unique cell death process that could help treat certain cancers by targeting the way tumors manage lipid oxidation.
- - A study has found that 7-dehydrocholesterol (7-DHC), which was thought to be harmful to neurons, actually helps cancer cells survive by protecting their membranes from oxidative damage.
- - In experiments with neuroblastoma and Burkitt's lymphoma, high levels of 7-DHC were linked to a shift in tumors that makes them more aggressive and resistant to ferroptosis, suggesting a potential cancer survival strategy.
The cytochrome P450 2C19 (CYP2C19) enzyme plays an important role in the metabolism of many commonly used drugs. Relatively little is known about CYP2C19 inhibitors, including compounds of natural origin, which could inhibit CYP2C19, potentially causing clinically relevant metabolism-based drug interactions. We evaluated a series (N = 49) of structurally related plant isoquinoline alkaloids for their abilities to interact with CYP2C19 enzyme using in vitro and in silico methods.
View Article and Find Full Text PDFWe prepared a number of N-phenethyltetrahydroisoquinolines structurally related to protoberberines. They were tested for activity against bacteria, fungi, and human leukemia HL-60 cells and also for inhibition of biosynthesis: ergosterol in yeasts and cholesterol in human cells. In the latter assay panel, several of the compounds were distinguished by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.
View Article and Find Full Text PDF