Publications by authors named "Aline Bolpetti"
Background:: Human papillomavirus (HPV) infection is a necessary cause for cervical cancer, but the majority of genital HPV infections clear spontaneously. Human leukocyte antigen (HLA) polymorphism influences immune response and genetic susceptibility, and its association with cervical cancer was extensively investigated, but few reports focused on HPV infection.
Methods:: We performed molecular typing of , , and genes as well as of HPV in 1226 women enrolled in the Ludwig-McGill cohort study and investigated the influence on cumulative HPV positivity.
Aims: To compare the cervicovaginal levels of human beta defensin (hBD)-1, 2 and 3 of women according to the status of Nugent-defined bacterial vaginosis (BV).
Methods: A total of 634 women of reproductive age were included in the study. Participants were equally distributed in two groups: according to the classification of vaginal smears according to Nugent criteria in normal (scores 0 to 3) and BV (scores ≥7).
Article Synopsis
- The study focused on women in Botucatu, Brazil, to investigate the levels of human β-defensins (hBD) during Chlamydia trachomatis infection.
- Cervicovaginal samples were analyzed for infections and local microbiota, revealing that women infected with C. trachomatis had significantly lower levels of hBD-1, hBD-2, and hBD-3 compared to those who were not infected.
- The findings suggest that a lower concentration of these defensins may be associated with the presence of C. trachomatis infection.
Tumors are complex structures containing different types of cells and molecules. The importance of the tumor microenvironment in tumor progression, growth, and maintenance is well-established. However, tumor effects are not restricted to the tumor microenvironment.
View Article and Find Full Text PDFBackground: Human Papillomavirus, HPV, is the main etiological factor for cervical cancer. Different studies show that in women infected with HPV there is a positive correlation between lesion grade and number of infiltrating macrophages, as well as with IL-10 higher expression. Using a HPV16 associated tumor model in mice, TC-1, our laboratory has demonstrated that tumor infiltrating macrophages are M2-like, induce T cell regulatory phenotype and play an important role in tumor growth.
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