Publications by authors named "Aline Bessa Veloso"
Aluminium-phthalocyanine chloride nanoemulsions for anticancer photodynamic therapy: Development and in vitro activity against monolayers and spheroids of human mammary adenocarcinoma MCF-7 cells.
Luis Alexandre Muehlmann Mosar Corrêa Rodrigues João Paulo Figueiró Longo Mônica Pereira Garcia Karen Rapp Py-Daniel Aline Bessa Veloso
J Nanobiotechnology
May 2015
Article Synopsis
- Photodynamic therapy (PDT) utilizes light and a photosensitizer like aluminium-phthalocyanine chloride (AlPc) to target and induce damage in cancer cells, but hydrophobic properties of AlPc necessitate a nanostructure for effective delivery.
- A nanoemulsion was successfully created using castor oil and Cremophor ELP®, resulting in nanodroplets around 25 nm in size, which significantly enhanced the photodynamic activity of AlPc against breast cancer cells.
- In vitro tests revealed that the nanoemulsion form of AlPc demonstrated potent cytotoxic effects, achieving a CC50 of 6.0 nM against MCF-7 cells, highlighting the potential of this approach for effective anticancer