Publications by authors named "Aline Beatriz Mello Rodrigues"
Multiple sclerosis (MS) is a neurological disease causing myelin and axon damage through inflammatory and autoimmune processes. Despite affecting millions worldwide, understanding its genetic pathways remains limited. The choroid plexus (ChP) has been studied in neurodegenerative processes and diseases like MS due to its dysregulation, yet its role in MS pathophysiology remains unclear.
View Article and Find Full Text PDFPlasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon.
Mem Inst Oswaldo Cruz
June 2021
Article Synopsis
- The study examined genetic diversity in Plasmodium vivax metacaspase 1 (PvMCA1) in Brazil's Juruá Valley, finding the complete genetic sequence identical among field isolates and a reference strain.
- Analysis of PvMCA1 across different global genomic sequences showed high conservation, with very few changes to critical amino acids related to its catalytic function.
- The genetic stability of PvMCA1 suggests it could be a viable target for drug development against vivax malaria.
Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia.
Parasit Vectors
April 2020
Background: The enzyme farnesyl diphosphate synthase (FPPS) is positioned in the intersection of different sterol biosynthesis pathways such as those producing isoprenoids, dolichols and ergosterol. FPPS is ubiquitous in eukaryotes and is inhibited by nitrogen-containing bisphosphonates (N-BP). N-BP activity and the mechanisms of cell death as well as damage to the ultrastructure due to N-BP has not yet been investigated in Leishmania infantum and Giardia.
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