Aripiprazole and topiramate, alone or in combination, block the expression of ethanol-induced conditioned place preference in mice.

Background: Ethanol is the most largely consumed drug in the world. Because of its complex mechanisms of action, studies suggest that the combination of drugs with distinct pharmacological effects may be a promising alternative for treating ethanol use disorder. In the present study, we aimed to investigate the effects of topiramate, alone and in combination with aripiprazole, on ethanol-induced conditioned place preference (CPP).

Context-dependent effects of rimonabant on ethanol-induced conditioned place preference in female mice.

Background: The CB1 receptor antagonist rimonabant has been previously found to prevent behavioral effects of drugs of abuse in a context-dependent manner, suggesting an important role of endocannabinoid signaling in drug-induced environmental conditioning. The aim of the present study was to evaluate the effects of rimonabant on ethanol-induced conditioned place preference (CPP) in female mice.

Methods: Animals were conditioned with saline or ethanol (1.