Publications by authors named "Aline A Alves"
Discriminating motilities: Coordinating IFT with flagellar beating patterns.
J Cell Biol
September 2024
Intraflagellar transport has traditionally been studied in immobilized flagella. In this issue, Gray et al. (https://doi.
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- Outer dynein arms (ODAs) play a crucial role in ciliary motility in eukaryotes, with LRRC56 protein being key for their maturation and attachment.
- Research shows that the absence of LRRC56 leads to a loss of ODAs, particularly in growing flagella, causing reduced motility and shorter flagella.
- The study highlights the interdependent relationship between LRRC56 and the docking complex proteins, revealing how disrupting cell division can partially compensate for the absence of distal ODAs but doesn't restore flagellum length.
The protist exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar pocket. This stage was so far described as replicative but immotile cells. Unexpectedly, the recent work of M.
View Article and Find Full Text PDFEukaryotic flagella are complex microtubule-based organelles that, in many organisms, contain extra-axonemal structures, such as the outer dense fibres of mammalian sperm and the paraflagellar rod (PFR) of trypanosomes. Flagellum assembly is a complex process occurring across three main compartments, the cytoplasm, the transition zone and the flagellum itself. The process begins with the translation of protein components followed by their sorting and trafficking into the flagellum, transport to the assembly site and incorporation.
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